I don't understand the question properly but from what I can infer I can tell you the following
The peers communicate among them through the channels. When you define a channel, you decide who is going to be part of it. Then, the transactions that are executed against that channel are viewed by all the members of the channel.
Users call the Peers and do the transactions
You don't do the transactions among Peers or between users. You call to a smart contract (chaincode in Hyperledger) that you have installed in a channel