You can try adding a class selector to the :not() pseudo-class like this:
:not(.printable) {
/* Styles */
}
Note: If you want better browser support (IE8 and older don't support :not()), then you're probably better off creating style rules for elements that do have the "printable" class. Even if that isn't feasible despite what you say about your actual markup, you will have to work your markup around that limitation. The important thing to remember is- Depending on the properties you're setting in this rule, some of them may either be inherited by descendants that are .printable, or otherwise affect them one way or another.
For example, even if the display is not inherited, setting display: none on a :not(.printable) will prevent it and all of its descendants from displaying because it removes the element and its subtree from layout completely. You can try using visibility: hidden instead which will allow visible descendants to show, but the hidden elements will still affect layout as they originally did.