Performance-wise if you see, In is much faster than OR operator.
If you are running a loop of 1000x the equivalent queries (for consistency, if you used sql_no_cache):
IN: 2.34969592094s
OR: 5.83781504631s
And if you are looking for some sample code to test this, then here's the simplest possible use case.
Raw SQL equivalent gets executed in the same manner if you are using Eloquent for syntax simplicity like this:
$t = microtime(true);
for($i=0; $i<10000; $i++):
$q = DB::table('users')->where('id',1)
->orWhere('id',2)
->orWhere('id',3)
->orWhere('id',4)
->orWhere('id',5)
->orWhere('id',6)
->orWhere('id',7)
->orWhere('id',8)
->orWhere('id',9)
->orWhere('id',10)
->orWhere('id',11)
->orWhere('id',12)
->orWhere('id',13)
->orWhere('id',14)
->orWhere('id',15)
->orWhere('id',16)
->orWhere('id',17)
->orWhere('id',18)
->orWhere('id',19)
->orWhere('id',20)->get();
endfor;
$t2 = microtime(true);
echo $t."\n".$t2."\n".($t2-$t)."\n";
1482080514.3635
1482080517.3713
3.0078368186951
$t = microtime(true);
for($i=0; $i<10000; $i++):
$q = DB::table('users')->whereIn('id',[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20])->get();
endfor;
$t2 = microtime(true);
echo $t."\n".$t2."\n".($t2-$t)."\n";
1482080534.0185
1482080536.178
2.1595389842987