MySQL INSERT Syntax does not support the WHERE clause so your query as it stands will fail. Assuming your id column is unique or primary key:
If you want to insert a new row with ID 1 then you use the below query:
INSERT INTO Users(id, weight, desiredWeight) VALUES(1, 160, 145);
But, If want to change the weight/desiredWeight values for an existing row with ID 1 then, use the below query:
UPDATE Users SET weight = 160, desiredWeight = 145 WHERE id = 1;
If you are trying to use INSERT .. ON DUPLICATE KEY syntax then, do like this:
INSERT INTO Users (id, weight, desiredWeight) VALUES(1, 160, 145) ON DUPLICATE KEY UPDATE weight=160, desiredWeight=145
Or do this:
INSERT INTO Users SET id=1, weight=160, desiredWeight=145 ON DUPLICATE KEY UPDATE weight=160, desiredWeight=145
Note: If the id column is an autoincrement column then you might as well omit it from your INSERT all together and let MySQL increment it as normal.