Mainframe developers upskilling for cloud computing and DevOps should prioritize learning cloud platforms like AWS, Azure, or Google Cloud, as well as containerization tools such as Docker and Kubernetes. They should also gain expertise in infrastructure-as-code (IAC) using tools like Terraform and learn CI/CD pipelines for automation. Familiarity with microservices architecture and scripting languages is crucial for a successful transition. If you are interested in entering the field of cloud computing, then check out this video about how Rakesh upskilled himself in cloud computing and devops with the help of Intellipaat’s Cloud Architect Course.