Use DataFrame.fillna to fill the nan's:
In [27]: df
Out[27]:
A B C
0 -0.166919 0.979728 -0.632955
1 -0.297953 -0.912674 -1.365463
2 -0.120211 -0.540679 -0.680481
3 NaN -2.027325 1.533582
4 NaN NaN 0.461821
5 -0.788073 NaN NaN
6 -0.916080 -0.612343 NaN
7 -0.887858 1.033826 NaN
8 1.948430 1.025011 -2.982224
9 0.019698 -0.795876 -0.046431
In [28]: df.mean()
Out[28]:
A -0.151121
B -0.231291
C -0.530307
dtype: float64
In [29]: df.fillna(df.mean())
Out[29]:
A B C
0 -0.166919 0.979728 -0.632955
1 -0.297953 -0.912674 -1.365463
2 -0.120211 -0.540679 -0.680481
3 -0.151121 -2.027325 1.533582
4 -0.151121 -0.231291 0.461821
5 -0.788073 -0.231291 -0.530307
6 -0.916080 -0.612343 -0.530307
7 -0.887858 1.033826 -0.530307
8 1.948430 1.025011 -2.982224
9 0.019698 -0.795876 -0.046431
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