Yes you can do that you set the autologin in raspi-config then create a shell script run.sh
python /path/to/project.manage.py runserver 0.0.0.0:8000
or you can use gunicorn proxy
You can also start other servers in this file
then put sh run.sh in you .bashrc.
You can install tmux by apt-get install tmux You can make detached session using tmux in run.sh using a unique name and tmux so that each time you open the prompt it wont create duplicate sessions.